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Point of Care Testing
Pathology Lab Manual
All Site Content
cANCA/pANCA, Autoimmune Vasculitis, ANCA
Values for Myeloperoxidase (MPO) antibody and Proteinase 3 antibody (PR3); if either is >=0.4 U, then cytoplasmic neutrophilic antibodies will be performed at an additional charge.
2.0 mL blood
Volume and Container
5.0 mL gold top SST blood tube
Storage and Transport
Serum stored refrigerated until ready for transport to Mayo Medical Laboratory Rochester
Causes for Rejection
Specimens other than serum, gross hemolysis, lipemia, icteric, warm serum
Turn Around Time
3-8 business days from time of collection
Monday-Friday from 8 am-5 pm, except observed holidays
CPT / HCPCS Code
83516x2, 86255, 86256 (if appropriate)
Evaluating patients suspected of having autoimmune vasculitis, both Wegener's granulomatosis and microscopic polyangiitis
Mayo Medical Laboratory Rochester
Test performed Monday-Saturday at Mayo Medical Laboratory Rochester
Multiplex flow immunoassay, Indirect immunofluorescence (if appropriate)
See reference lab report
Limitations and Contraindications
Positive results PR3 ANCA and cANCA or pANCA are consistent with the diagnosis of WG, either systemic WG with respiratory and renal involvement or limited WG with more restricted end-organ involvement. Positive results for MPO ANCA and pANCA are consistent with the diagnosis of autoimmune vasculitis including MPA or pauci-immune necrotizing glomerulonephritis.
CPOE Test Name
Ref ANCAP, Ref ANCA Vasculitis
Created at 9/8/2014 5:57 PM by Bradshaw, Keir
Last modified at 9/8/2014 5:57 PM by Bradshaw, Keir
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