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Point of Care Testing
Pathology Lab Manual
All Site Content
Autoantibodies to Histones, Histone Autoantibodies, Anti-Histone
2.0 mL blood
Volume and Container
5.0 mL gold top SST blood tube
Storage and Transport
Serum stored refrigerated until ready for transport to Mayo Medical Laboratory Rochester
Causes for Rejection
Specimens other than serum, gross hemolysis, warm serum, gross lipemia
Turn Around Time
3-8 business days from time of collection
Monday-Friday from 8 am-5 pm, except observed holidays
CPT / HCPCS Code
Evaluating patients suspected of having drug-induced lupus
Mayo Medical Laboratory Rochester
Test performed Monday, Wednesday, Friday at Mayo Medical Laboratory Rochester
See reference lab report
Limitations and Contraindications
Testing for histone is not necessary to establish the diagnosis of SLE, test results not useful for determining prognosis in patients with SLE or drug-induced lupus
A positive result for histone with a negative result for dsDNA is consistent with drug-induced lupus. A positive result for histone with a positive result for dsDNA is consistent with SLE
CPOE Test Name
Ref Anti-Histone, Ref HIST
Created at 9/8/2014 5:57 PM by Bradshaw, Keir
Last modified at 9/8/2014 5:57 PM by Bradshaw, Keir
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