Skip Ribbon Commands
Skip to main content

Pathology

:

pawsPathologyManual: Autoantibodies to Histone

Lonic Code

 

Test Name

Autoantibodies to Histone

Synonyms

Histone Autoantibodies

Test Consists

 

Specimen Requirements

1 mL blood

Volume and Container

5.0 mL Gold top SST tube

Storage and Transport

Serum stored refrigerated until ready for transport to Mayo Medical Laboratory Rochester

Critical Values

 

Causes for Rejection

Specimens other than serum, warm serum

Turn Around Time

3-8 business days from time of collection

Availability

Monday-Friday from 8 am-5 pm, except observed holidays.

CPT / HCPCS Code

83516

Medicare Fee

 

Comments

 

Row Stamp

38,869,169

Last Updated

 

Volume

 

Minimum Volume

 

Indications

Evaluating patients suspected of having drug-induced lupus erythematosus

Professional Fee

 

Tech Charge

 

Total Fee

 

Special Instructions

CPOE: Ref HIST or Ref Anti-Histone

Lab

Mayo Medical Laboratory Rochester

Schedule

Test performed Monday, Wednesday, Friday at Mayo Medical Laboratory Rochester

Request Form

Rheumatology Orders/Mail outs

Methodology

ELISA (Enzyme-Linked Immunosorbent Assay)

Patient Prep

 

Post Processing

 

Collection Guidelines

 

Reference Range

Negative at <1.0 U; Borderline at 1.0-1.5 U; Positive at >1.5 U

Limitations and Contraindications

Positive histone occur in some patients exposed to procainamide, hydralazine, quinidine, alpha methyldopa, penicillamine, and isoniazid who do not have signs or symptoms of LE.

Interpretation

A positive histone with a negative dsDNA ab is consistent with drug-induced LE. A positive histone with a positive dsDNA is consistent with idiopathic LE

Additional Information

 

CPOE Test Name

Ref HIST or Ref Anti-Histone

Status

0

AUDIT_DEL

Waters, Laura S.

Attachments

Created at 9/8/2014 5:57 PM by Bradshaw, Keir
Last modified at 9/8/2014 5:57 PM by Bradshaw, Keir